Lack of group-to-individual generalizability in people with lower urinary tract symptoms emphasizes the need for deep phenotyping and personalized treatments
Lack of group-to-individual generalizability previously shown for psychological symptoms is confirmed for LUTS. Wealth of information on the co-occurrence and co-evolution of LUTS in the intra-individual correlations and cosine similarities corroborates heterogeneity of LUTS and can be useful for deep phenotyping and for identifying personalized treatments of LUTS.
Authors
- James Quentin Clemens (ORCID: https://orcid.org/0000-0002-0759-3385)
- Brian A. Bieber (ORCID: https://orcid.org/0000-0001-8505-0979)
- Caroline Smerdon
- Victor P. Andreev (ORCID: https://orcid.org/0000-0003-3812-1230)
- Claire C. Yang (ORCID: https://orcid.org/0000-0002-4750-6258)
- Abigail R. Smith (ORCID: https://orcid.org/0000-0001-5496-4460)
- David F Cella (ORCID: https://orcid.org/0000-0002-9881-4541)
- Kathryn E. Flynn (ORCID: https://orcid.org/0000-0002-4427-3583)
- Ziya Kırkalı
- Kevin P. Weinfurt (ORCID: https://orcid.org/0000-0002-0624-7448)
Institutions
- Northwestern University (US)
- Duke University (US)
- University of Washington (US)
- Medical College of Wisconsin (US)
- University of Michigan (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- Northwestern University (PH)
- Michigan Medicine (US)
- Arbor Research Collaborative for Health (US)
- Northwestern Medicine (US)
Publication Details
- Journal
- Journal of Clinical and Translational Science
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/cts.2025.10113
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Northwestern University
- Washington University in St. Louis
- University of Washington
- University of Cambridge
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Center for Advancing Translational Sciences