MicroRNA Expression and Neurocognitive Outcomes in Children and Young People With Primary Brain Tumor in Karachi, Pakistan: A Pilot Exploratory Study
This pilot exploratory study found two statistically significant correlations: a negative correlation between pretreatment miR-210 levels and 12 months posttreatment perceptual reasoning scores and a positive correlation between miR-10b expression and 12 months posttreatment speed scores. Further studies are needed to understand the protective or restorative function of miR-10b in cognitive processes and the detrimental role of miR-210 in cognitive processes to evaluate their potential future use as prognostic biomarkers for neurocognitive outcomes in children and young people with primary brain tumors.
Authors
- Iqbal Azam (ORCID: https://orcid.org/0000-0003-0766-4064)
- Thomas Mårtensson (ORCID: https://orcid.org/0000-0002-4074-2653)
- Nouman Mughal (ORCID: https://orcid.org/0000-0002-3298-3959)
- Salman Kirmani (ORCID: https://orcid.org/0000-0003-2039-5233)
- Naureen Mushtaq (ORCID: https://orcid.org/0000-0002-5461-3350)
- Farrukh Javeed (ORCID: https://orcid.org/0000-0002-7433-4834)
- Nida Zahid (ORCID: https://orcid.org/0000-0001-8812-9463)
- Nick Brown (ORCID: https://orcid.org/0000-0003-1789-0436)
- Lal Rehman (ORCID: https://orcid.org/0000-0002-0624-3420)
- Andreas Mårtensson (ORCID: https://orcid.org/0000-0001-7504-8365)
- Mariya Moochhala
- Syed Ather Enam (ORCID: https://orcid.org/0000-0003-2194-0723)
- Wajiha Amin (ORCID: https://orcid.org/0009-0005-4543-2258)
- Muhammad Ibrahim (ORCID: https://orcid.org/0000-0002-1496-0892)
- Sana Naeem
- Aneesa Hasan
- Faiza Kausar
- S. Qazi
- Sadaf Altaf
Institutions
- Aga Khan University (PK)
- Uppsala University (SE)
- Jinnah Postgraduate Medical Center (PK)
Publication Details
- Journal
- Brain Tumor Research and Treatment
- Published
- 2025-01-01
- DOI
- https://doi.org/10.14791/btrt.2025.0006
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00