Exploring New Frontiers in Patent Fossa Ovalis Closure

Percutaneous closure of patent fossa ovalis in patients with paradoxical embolism has gradually emerged as an increasingly compelling alternative to prolonged medical therapy. In particular, in recent years, percutaneous suture‐mediated “deviceless” patent fossa ovalis closure has emerged as a revolutionary technique, offering feasibility across diverse septal anatomies and improved safety compared to implantable devices, while ensuring substantially comparable efficacy in achieving patent fossa ovalis closure. The innovative nature of percutaneous suture‐mediated patent fossa ovalis closure offers a number of advantages that suggest it as the preferred primary treatment choice for patent fossa ovalis closure when feasible. Although the need for long‐term follow‐up data remains, controlled studies are ongoing to provide a deeper understanding of its efficacy and durability. In addition, percutaneous suture‐mediated patent fossa ovalis closure has promising prospects beyond preventive indications in patients with a history of migraine, the elderly, and divers. The evolving landscape of percutaneous suture‐mediated patent fossa ovalis closure is transformative, demonstrating a paradigm shift in patient care options and redefining therapeutic approaches for patent fossa ovalis–related conditions.