A visible-light-promoted perfluoroalkylation/cyclization cascade towards perfluoroalkyl-substituted iminoisobenzofurans using the EDA complex
Perfluoroalkyl-functionalized heterocycles exhibit profoundly modified bioactivities, motivating the development of efficient methods for precise perfluoroalkyl group installation. A new metal-free photoinduced radical-initiated cascade reaction was developed for the rapid synthesis of perfluoroalkyl-substituted iminoisobenzofurans by reacting various perfluoroalkyl iodides (R<sub>F</sub>-I) under mild reaction conditions. In this reaction system, the formation of electron donor-acceptor (EDA) complexes is pivotal for the visible-light promoted transformation in the absence of additional photocatalytic species.
Authors
- Zhenhua Zhang (ORCID: https://orcid.org/0000-0002-6579-1670)
- Mingxi Hu (ORCID: https://orcid.org/0000-0002-3813-9222)
- Pifeng Wei
- Shuo Gao (ORCID: https://orcid.org/0000-0002-1571-6429)
- Mengmeng Zhao (ORCID: https://orcid.org/0000-0002-3769-008X)
- Zilin Liu (ORCID: https://orcid.org/0000-0002-2746-2673)
Institutions
- Linyi University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob00888c
- Citations
- 5
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 3.95
Funders
- National Natural Science Foundation of China
- Linyi University
- Natural Science Foundation of Shandong Province