The sympathoadrenal contribution to inferior vena cava formation

Abstract Although vascular development is fundamental during embryogenesis, the developmental basis and tissue interactions underlying anatomical variation in major veins are not fully understood. The renal segment of the inferior vena cava exhibits significant anatomical variations that often affect the safety of retroperitoneal surgery. Using mouse embryos, we show that the renal segment of the inferior vena cava is not primarily dependent on the subcardinal vein as classically proposed, but instead forms from a vascular plexus closely associated with the developing para-aortic ridge. Genetic models further indicate that sympathoadrenal development in the para-aortic ridge contributes to the proper organization and remodeling of this vascular network. This revised developmental framework highlights a sympathoadrenal–vascular coupling as a developmental basis for inferior vena cava formation and thereby challenges classical subcardinal vein-dependent models.

Authors

Institutions

Publication Details

Journal
Communications Biology
Published
2026-11-07
DOI
https://doi.org/10.1038/s42003-026-11297-3
Primary Topic
Vascular anomalies and interventions
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
NOV
article

The sympathoadrenal contribution to inferior vena cava formation

Yuichi Shima, Yoshiaki Kubota, Sumio Isogai, Jiro Hitomi et al.
Communications Biology
Vascular anomalies and interventions
article

The sympathoadrenal contribution to inferior vena cava formation

Yuichi Shima, Yoshiaki Kubota, Sumio Isogai, Jiro Hitomi, Daisuke Matsumaru, Takatoshi Ueki, Aki Murashima, Takashi Moriguchi, Chikako Yokoyama, Ken-ichirou Morohashi
article en

Abstract

Abstract Although vascular development is fundamental during embryogenesis, the developmental basis and tissue interactions underlying anatomical variation in major veins are not fully understood. The renal segment of the inferior vena cava exhibits significant anatomical variations that often affect the safety of retroperitoneal surgery. Using mouse embryos, we show that the renal segment of the inferior vena cava is not primarily dependent on the subcardinal vein as classically proposed, but instead forms from a vascular plexus closely associated with the developing para-aortic ridge. Genetic models further indicate that sympathoadrenal development in the para-aortic ridge contributes to the proper organization and remodeling of this vascular network. This revised developmental framework highlights a sympathoadrenal–vascular coupling as a developmental basis for inferior vena cava formation and thereby challenges classical subcardinal vein-dependent models.

Communications Biology
Kurume University (JP), Gifu Pharmaceutical University (JP), Iwate Medical University (JP), Keio University (JP), Nagoya City University (JP), Osaka Metropolitan University (JP), Tohoku Medical and Pharmaceutical University (JP)
Nagoya City University, National Institutes of Health, Medical School, University of Michigan, Japan Society for the Promotion of Science
Good health and well-being
Openalex Percentile: Top 100%
Vascular anomalies and interventions
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Laika access coming soon