Aconitate Decarboxylase 1 Downregulates Colitis and Maintains Homeostasis of the Gut Metabolome and Microbiome
While ACOD1 is increased in human inflammatory bowel disease tissues, our data indicate that this enzyme has a protective role in acute and chronic experimental colitis and is associated with prevention of intestinal dysbiosis and stabilization of the metabolome.
Authors
- M. Blanca Piazuelo
- Alain P. Gobert (ORCID: https://orcid.org/0000-0001-7535-539X)
- Kamery J. Williams
- Yvonne L. Latour (ORCID: https://orcid.org/0000-0002-9319-8268)
- Margaret M. Allaman (ORCID: https://orcid.org/0000-0002-2803-1365)
- Keith T. Wilson (ORCID: https://orcid.org/0000-0003-4421-1830)
- Caroline V. Hawkins
- Sergei Chetyrkin (ORCID: https://orcid.org/0009-0005-2589-5394)
- Kara M. McNamara (ORCID: https://orcid.org/0000-0001-9347-0009)
- Daniel P. Barry (ORCID: https://orcid.org/0000-0002-3972-3914)
- M. Wade Calcutt (ORCID: https://orcid.org/0000-0002-8002-4699)
- Lori A. Coburn (ORCID: https://orcid.org/0000-0003-3249-9806)
- Shilin Zhao (ORCID: https://orcid.org/0000-0002-3921-3965)
- M. Kay Washington (ORCID: https://orcid.org/0000-0002-9589-7695)
- Alberto G. Delgado
Institutions
- Vanderbilt University (US)
- VA Tennessee Valley Healthcare System (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Gastro Hep Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.gastha.2025.100748
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- U.S. Department of Defense
- U.S. Department of Veterans Affairs
- Vanderbilt University
- Crohn's and Colitis Foundation
- Vanderbilt University Medical Center
- National Institutes of Health
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases