Retro-Walking and Cholinergic Network Correlates in Parkinson’s Disease
Our findings indicate that retro-walking places greater demands on brain cholinergic synaptic integrity involving subcortical-frontal and temporal cortical regions, subserving balance-particularly reactive postural control-and attentional resources compared to forward walking. Our results suggest that retro-walking might serve as part of an intervention strategy to improve balance and cognition in PwP.
Authors
- Prabesh Kanel (ORCID: https://orcid.org/0000-0003-1418-2960)
- Miriam van Emde Boas (ORCID: https://orcid.org/0009-0008-3942-3330)
- Stiven Roytman (ORCID: https://orcid.org/0000-0001-8823-3287)
- Chatkaew Pongmala (ORCID: https://orcid.org/0000-0002-1738-0105)
- Taylor Brown (ORCID: https://orcid.org/0009-0004-6421-1007)
- Nicolaas Ida Bohnen (ORCID: https://orcid.org/0000-0003-0352-6414)
- Alexis Griggs (ORCID: https://orcid.org/0000-0001-5215-0199)
- Giulia Carli
Institutions
- University of Michigan (US)
- VA Ann Arbor Healthcare System (US)
- Geriatric Research Education and Clinical Center (US)
- Michigan United (US)
- Michigan Medicine (US)
- Cognitive Neuroimaging Lab (FR)
- Parkinson's Foundation (US)
Publication Details
- Journal
- Journal of Movement Disorders
- Published
- 2025-07-30
- DOI
- https://doi.org/10.14802/jmd.25109
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00