DIAGNOSTIC AND PROGNOSTIC SIGNIFICANCE OF PINP AND Β-CROSSLAPS IN PEDIATRIC ACUTE HEMATOGENOUS OSTEOMYELITIS.

The use of the P/B index enables individualized treatment, timely adjustment of mechanical loading and antibiotic therapy, and the prevention of complications. Integrating PINP, β-CrossLaps, and the P/B index into clinical practice improves diagnostic accuracy, enhances monitoring efficiency, and leads to better outcomes in children with acute osteomyelitis. A personalized monitoring algorithm covering all stages of the disease is proposed.