Genetic markers involved in neuroinflammation in Down syndrome: a systematic review
The findings highlight the role of neuroinflammation in neurodegenerative disorders in individuals with DS, especially Alzheimer's disease. Some studies indicated that the triplicated genes SOD1, APP, S100B, TREM2, IFNR1, and IFNR2 are directly related to neuroinflammation. Additionally, elevated levels of pro-inflammatory cytokines, such as IL-1, IL-6, IL-10, IFNγ, and TNF-α, and complement proteins like C1q, C3, and C9 suggest an exacerbated activation of the immune response. However, the roles these genes may play in neurodegenerative diseases and in increasing or reducing neuroinflammation remain controversial.
Authors
- Juliana Álvares-Teodoro (ORCID: https://orcid.org/0000-0002-0210-0721)
- Marcus Carvalho Borin (ORCID: https://orcid.org/0000-0002-0918-6505)
- Francisco de Assis Acúrcio (ORCID: https://orcid.org/0000-0002-5880-5261)
- Mariana Dias Lula (ORCID: https://orcid.org/0000-0003-0760-4424)
- Augusto Afonso Guerra (ORCID: https://orcid.org/0000-0001-5256-0577)
- Bárbara Rodrigues Alvernaz dos Santos (ORCID: https://orcid.org/0000-0001-9796-4321)
- Mara Dalila Almeida e Silva (ORCID: https://orcid.org/0009-0001-1379-735X)
- Lívia Silva Nassif (ORCID: https://orcid.org/0009-0004-8921-8803)
- Lucas Reis Felício (ORCID: https://orcid.org/0009-0001-5834-6800)
Institutions
- Universidade Federal de Minas Gerais (BR)
Publication Details
- Journal
- Dementia & Neuropsychologia
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1590/1980-5764-dn-2024-0251
- Citations
- 1
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 1.88