Elevated Spleen Tyrosine Kinase in Low-Density Neutrophils During Bacterial Sepsis in a Nonhuman Primate Model
Bacterial sepsis leads to heterogenous populations of circulating neutrophils, including LDNs. Elevated SYK expression in WBNs and LDNs correlates with end-organ dysfunction, highlighting SYK as a potential therapeutic target in bacterial sepsis.
Authors
- Richard Herbert
- Kevin M. Vannella (ORCID: https://orcid.org/0000-0002-0972-5011)
- Hammed Hassan Adetola (ORCID: https://orcid.org/0000-0002-5811-4436)
- Andrew P. Platt (ORCID: https://orcid.org/0000-0001-8481-114X)
- Daniel S. Chertow (ORCID: https://orcid.org/0000-0002-1675-1728)
- Derron A. Alves
- Heather Kendall
- Kiana C Allen (ORCID: https://orcid.org/0009-0009-1182-5749)
- Marcos Javier Ramos-Benítez (ORCID: https://orcid.org/0000-0001-9445-3294)
- Ramón Cruz (ORCID: https://orcid.org/0000-0002-1308-5993)
- Izabella Lach
- Sydney Stein (ORCID: https://orcid.org/0000-0002-0259-4485)
- Sabrina Ramelli (ORCID: https://orcid.org/0000-0001-5428-2814)
- Seth Warner (ORCID: https://orcid.org/0009-0001-4571-9188)
- Jeffrey R. Strich (ORCID: https://orcid.org/0000-0002-5671-1130)
- Shelly Curran (ORCID: https://orcid.org/0009-0005-2379-627X)
- Heather Teague (ORCID: https://orcid.org/0000-0001-6013-4252)
- Trevor M. Stantliff (ORCID: https://orcid.org/0000-0003-2621-3111)
- Mahnaz Minai
Institutions
- Ponce Health Sciences University (PR)
- National Heart, Lung, and Blood Institute (US)
- National Institute of Allergy and Infectious Diseases (US)
- National Institutes of Health Clinical Center (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-07-30
- DOI
- https://doi.org/10.1093/infdis/jiaf403
- Citations
- 1
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35