Characterization of MAIT cells in glioblastoma reveals a potential immunosuppressive role through a MAIT-neutrophil axis
These findings revealed an immunosuppressive role of MAIT cells in GBM and highlighted the MAIT-TAN axis as a potential novel therapeutic target to modulate GBM's immunosuppressive tumor microenvironment.
Authors
- Matthew Watowich
- Taijun Hana (ORCID: https://orcid.org/0000-0001-7649-3305)
- Robert Michael Prins (ORCID: https://orcid.org/0000-0002-6282-6583)
- George Zaki (ORCID: https://orcid.org/0000-0002-2740-3307)
- Guzal Khayrullina (ORCID: https://orcid.org/0000-0002-9130-4274)
- Patrick J. Cimino (ORCID: https://orcid.org/0000-0003-0441-4502)
- Noémi Kedei (ORCID: https://orcid.org/0000-0002-6625-6119)
- Masashi Watanabe
- Mark R. Gilbert (ORCID: https://orcid.org/0000-0003-2556-9722)
- Ananth Hari (ORCID: https://orcid.org/0000-0001-8174-5335)
- Benjamin Ruf (ORCID: https://orcid.org/0000-0002-2501-4471)
- Hye Min Kim (ORCID: https://orcid.org/0000-0002-2899-9480)
- Alexander Lee (ORCID: https://orcid.org/0000-0001-6237-5498)
- Masaki Terabe (ORCID: https://orcid.org/0000-0002-1777-0189)
- Ayaka Hara
- Michael Ford (ORCID: https://orcid.org/0000-0001-9451-3541)
- S. Cenk Şahinalp (ORCID: https://orcid.org/0000-0002-2170-2808)
- M. M. Coombs
- Seketoulie Keretsu
- Nargis Malik (ORCID: https://orcid.org/0000-0003-1294-1660)
- Jo Spurgeon
Institutions
- National Institutes of Health (US)
- Medical Protective (US)
- UCLA Health (US)
- American Society for Gastrointestinal Endoscopy (US)
- UCLA Medical Center (US)
- Office of the Director (US)
- Center for Neuro-Oncology (US)
- Parker Institute for Cancer Immunotherapy (US)
- National Institute of Neurological Disorders and Stroke (US)
- University Children's Hospital Tübingen (DE)
- Frederick National Laboratory for Cancer Research (US)
- National Cancer Institute (MY)
- National Cancer Institute (US)
- Center for Cancer Research (US)
- Guided Therapeutics (United States) (US)
- University of Tübingen (DE)
Publication Details
- Journal
- Neuro-Oncology Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/noajnl/vdaf173
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Parker Institute for Cancer Immunotherapy
- National Institutes of Health
- National Cancer Institute
- NIH Clinical Center