Efficient removal of antibody aggregates using TOYOPEARL MX-Trp-650M mixed-mode resin under salt or pH gradient elution

Combining the results from prior studies, the current data confirm the strong aggregate separation capability of MX-Trp-650M. The results also suggest that the optimal elution conditions for efficacious separation may vary across different antibody purification scenarios.

Authors

Penglong Zhang
Jinyi Zhang (ORCID: https://orcid.org/0000-0001-9583-6406)
Yifeng Li (ORCID: https://orcid.org/0009-0002-6994-9276)

Institutions

WuXi AppTec (China) (CN)

Publication Details

Journal: Journal of Biological Methods
Published: 2025-07-30
DOI: https://doi.org/10.14440/jbm.0029
Primary Topic: Protein purification and stability
Type: article
Field-Weighted Citation Impact: 0.00

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article

Efficient removal of antibody aggregates using TOYOPEARL MX-Trp-650M mixed-mode resin under salt or pH gradient elution

Penglong Zhang, Jinyi Zhang, Yifeng Li

Jul 30, 2025

Journal of Biological Methods

Protein purification and stability

article

Efficient removal of antibody aggregates using TOYOPEARL MX-Trp-650M mixed-mode resin under salt or pH gradient elution

Penglong Zhang, Jinyi Zhang, Yifeng Li

July 30, 2025article en

Abstract

Journal of Biological MethodsVol. 12(3)

WuXi AppTec (China) (CN)

Openalex Percentile: Top 83%

Protein purification and stability

DOI Open Access PDF OpenAlex

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Efficient removal of antibody aggregates using TOYOPEARL MX-Trp-650M mixed-mode resin under salt or pH gradient elution — Penglong Zhang, Jinyi Zhang, et al. · Journal of Biological Methods (2025) | TGRS Research Map | TGRS