Hypofractionated stereotactic radiotherapy versus whole-brain radiotherapy following brain metastasis resection: Results of the ESTRON randomized phase 2 trial
Survival was similar for HFSRT and WBRT, while WBRT trended toward better ic-PFS. HFSRT showed substantially lower toxicity and better neurocognitive preservation, however, a higher risk of LMD. Risks and benefits should be weighed individually when determining post-operative treatment for BM.
Authors
- Rami A. El Shafie (ORCID: https://orcid.org/0000-0002-1355-7882)
- Kristin Lang (ORCID: https://orcid.org/0000-0002-5355-3173)
- Thomas Welzel (ORCID: https://orcid.org/0000-0001-9960-3052)
- Farastuk Bozorgmehr (ORCID: https://orcid.org/0000-0001-8058-8884)
- Daniela Schmitt (ORCID: https://orcid.org/0000-0002-9657-0715)
- Laila König (ORCID: https://orcid.org/0000-0001-8402-6694)
- Michael Thomas (ORCID: https://orcid.org/0000-0002-4121-3091)
- Sinem Erdem
- Meinhard Kieser (ORCID: https://orcid.org/0000-0003-2402-4333)
- Cornelia Jäkel
- Denise Bernhardt (ORCID: https://orcid.org/0000-0001-5231-9097)
- Sebastian Adeberg (ORCID: https://orcid.org/0000-0001-8463-514X)
- Stefan Rieken
- Annabella Schiele
- Fabian Weykamp (ORCID: https://orcid.org/0000-0003-1731-7090)
- Tanja Eichkorn (ORCID: https://orcid.org/0000-0003-0150-1328)
- Paul Thalmann
- Jürgen Debus
- Anja Sander
- Adriane Lentz-Hommertgen
- Angela Paul
Institutions
- Philipps University of Marburg (DE)
- Zimmer Biomet (Netherlands) (NL)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- TUM Klinikum (DE)
- Zimmer Biomet (Germany) (DE)
- Heidelberger Institut für Radioonkologie (DE)
- National Center for Tumor Diseases (DE)
- Universitätsmedizin Göttingen (DE)
- German Center for Lung Research (DE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-07-30
- DOI
- https://doi.org/10.1093/neuonc/noaf182
- Citations
- 1
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Accuray