Process design and modeling to achieve high yield and optimum purity for continuous synthesis of carbamazepine
Study uses kinetic modeling to optimize continuous synthesis, boosting yield and impurity control. It underscores the role of reaction conditions to enhance purity, complementing traditional purification strategies.
Authors
- Dongkai Zhu (ORCID: https://orcid.org/0000-0002-0929-3773)
- Adil Mohammad (ORCID: https://orcid.org/0000-0003-0310-1088)
- Harrison F. Kraus (ORCID: https://orcid.org/0000-0003-0716-6110)
- David Acevedo (ORCID: https://orcid.org/0000-0003-3967-8719)
- Dongxia Liu (ORCID: https://orcid.org/0000-0001-8712-2219)
- Yuan Zhang (ORCID: https://orcid.org/0000-0001-8116-6296)
Institutions
- United States Food and Drug Administration (US)
- Center for Drug Evaluation and Research (US)
- University of Maryland, College Park (US)
- University of Delaware (US)
Publication Details
- Journal
- Reaction Chemistry & Engineering
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5re00088b
- Primary Topic
- Innovative Microfluidic and Catalytic Techniques Innovation
- Type
- article
- Field-Weighted Citation Impact
- 0.00