Construction Strategies and Application Research of Polysaccharide-Nanoparticle Composite Delivery Systems

Background: Polysaccharides exhibit multiple biological activities and are used as delivery systems due to their molecular designability, degradability, and targeting properties. However, their high molecular weight, poor water solubility, and instability pose bottlenecks to their application. The addition of nanoparticles can improve the functions of polysaccharide delivery systems, but there are relatively few summary articles on polysaccharide-nanoparticle composite delivery systems and their construction strategies.Methods: This paper evaluates relevant articles on polysaccharides, nanoparticles, and their composite delivery systems. The search focused on keywords closely related to the theme, such as "chitosan", "hyaluronic acid", "nanoparticles", "construction strategies", "targeting", etc. The search process was carried out using databases such as Web of Science, Google Scholar, and PubMed.Results: The construction and application of polysaccharide-nanoparticle composite delivery systems were discussed from the aspects of raw materials, construction strategies, functions and advantages, applications, etc.Conclusions: Polysaccharide-nanoparticle composite delivery systems have synergistic effects compared with single delivery systems, which helps to enhance the efficacy of the delivery system and is of great significance for promoting the application of polysaccharide-nanoparticle composite systems in various delivery scenarios.