Nickel Bioaccumulation in Oral Biofilm, Gingival Tissue, and Saliva During Fixed Orthodontic Treatment: A 12-Month Prospective Cohort Study on Predictors and Salivary pH Correlation
Oral biofilm serves as the dominant long-term nickel reservoir during orthodontic treatment, with accumulation dynamics influenced by treatment duration, pH, and age. The pH-dependent biofilm-metal interaction highlights its potential as a biomarker for exposure monitoring and a target for preventive strategies. These findings support the development of pH-modulating oral care protocols and corrosion-resistant orthodontic materials to mitigate nickel exposure risks. <b>Key words:</b>Nickel, saliva, Spectrophotometry, Atomic, Orthodontic Appliances, Hydrogen-Ion Concentration.
Authors
- Alejandra Herrera (ORCID: https://orcid.org/0000-0001-5830-5868)
- Carlos M. Ardila (ORCID: https://orcid.org/0000-0002-3663-1416)
- Jaime Plazas-Román (ORCID: https://orcid.org/0000-0002-5040-6899)
- Antonio Díaz Caballero (ORCID: https://orcid.org/0000-0001-9693-2969)
- Lizeth Galviz-García
- Jairo Mercado‐Camargo (ORCID: https://orcid.org/0000-0002-1686-0924)
- Sonia Romero‐Romero (ORCID: https://orcid.org/0000-0003-4683-8805)
Institutions
- Universidad Tecnológica de Bolívar (CO)
- University of Cartagena (CO)
- Universidad de Antioquia (CO)
- Universidad Metropolitana (CO)
- Universidad del Sinú (CO)
- Saveetha University (IN)
Publication Details
- Journal
- Journal of Clinical and Experimental Dentistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.4317/jced.62923
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 0.00