Retrospective analysis of primary pulmonary lymphoma cases from Polish Lymphoma Research Group centers reveals associations between initial symptoms and outcomes
Primary pulmonary lymphoma (PPL) is a rare extranodal lymphoma, accounting for only 0.4% of all lymphomas. We conducted a retrospective analysis of 78 patients with PPL treated at 15 tertiary care hematooncology centers in Poland. The study revealed a high incidence of aggressive B-cell lymphoma (42%), although this may reflect the specificity of participating centers. A high prevalence of pleural effusion and dyspnea at the time of diagnosis was found to be associated with worse overall survival in all PPL patients. Dyspnea and bilateral lung lesions at presentation were associated with a lack of complete remission, while the presence of cough was associated with shorter time to disease progression or relapse. Although the progression-free survival did not differ significantly between patients with low- versus high-grade B-cell PPLs, those with indolent PPLs exhibited superior overall survival. To the best of our knowledge, this study is the first multicenter retrospective analysis of PPL in Central Europe involving such a large cohort of patients.
Authors
- Jan Maciej Zaucha (ORCID: https://orcid.org/0000-0002-0986-8936)
- Ewa Paszkiewicz‐Kozik (ORCID: https://orcid.org/0000-0003-2629-3932)
- Michal K. Handzlik (ORCID: https://orcid.org/0000-0002-4653-1902)
- Magdalena Witkowska (ORCID: https://orcid.org/0000-0002-3942-0753)
- Renata Guzicka‐Kazimierczak (ORCID: https://orcid.org/0000-0002-7534-804X)
- Aleksander Kania (ORCID: https://orcid.org/0000-0001-5181-4360)
- Paweł Kurczab
- Sebastian Giebel (ORCID: https://orcid.org/0000-0002-4827-4401)
- Agnieszka Giza
- Joanna Romejko‐Jarosińska (ORCID: https://orcid.org/0000-0003-4603-1112)
- Joanna Ewa Drozd-Sokolowska (ORCID: https://orcid.org/0000-0002-4562-6264)
- Ewa Kalinka‐Warzocha (ORCID: https://orcid.org/0000-0003-4791-8372)
- Marta Morawska (ORCID: https://orcid.org/0000-0001-6836-2903)
- Dana Elena Giza (ORCID: https://orcid.org/0000-0003-0887-5883)
- Paulina Dumnicka (ORCID: https://orcid.org/0000-0003-3667-857X)
- Wanda Knopińska‐Posłuszny
- Elżbieta Kalicińska (ORCID: https://orcid.org/0000-0002-4797-8001)
- Dagmara Zimowska‐Curyło (ORCID: https://orcid.org/0000-0002-4117-3667)
- Grażyna Siewior
- Tomasz Wróbel (ORCID: https://orcid.org/0000-0001-9194-9753)
Institutions
- Medical University of Lublin (PL)
- Jagiellonian University (PL)
- Medical University of Silesia (PL)
- Medical University of Warsaw (PL)
- Wroclaw Medical University (PL)
- National Institute of Oncology (HU)
- Medical University of Lodz (PL)
- Gdynia Maritime University (PL)
- Polish Mother’s Memorial Hospital Research Institute (PL)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- School of Administration in Bielsko-Biala (PL)
- University of Bielsko-Biała (PL)
- Gdańsk Medical University (PL)
- Pomeranian Medical University (PL)
- University of Rzeszów (PL)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-07-30
- DOI
- https://doi.org/10.1038/s41598-025-12469-7
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Uniwersytet Jagielloński Collegium Medicum