The Role of the Creatine Phosphate System in Energy Storage and Release: From Molecular Mechanisms to Physiological Functions

The creatine phosphate system helps process energy in cells, especially in tissues that require a lot of energy and change quickly, such as muscles and brains. This study mainly talks about how the creatine phosphate system works, its basic principles, the pathways involved, and its role in the body. We focused on creatine kinase, which helps cells regenerate ATP, and also plays a role in "storing" energy, and is even responsible for transmitting energy to where it is needed. This process is very critical during muscle contraction and brain function, especially in those organs that use a lot of energy, it can help cells maintain a stable energy state. The article also mentioned that supplementing creatine phosphate may help some diseases, such as muscle diseases and neurodegenerative diseases. Now, because of the increasing advancement of technologies such as molecular imaging and bioinformatics, people have a deeper understanding of how creatine is metabolized and how it cooperates with other cellular processes. In the future, researchers may try to develop some new therapies related to creatine. We will continue to explore how it is regulated at the molecular level and see how it is related to other metabolic pathways. These studies are expected to bring new ideas and treatments for treating some energy-related diseases.

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Publication Details

Journal
Journal of Energy Bioscience
Published
2025-01-01
DOI
https://doi.org/10.5376/jeb.2025.16.0005
Primary Topic
Muscle metabolism and nutrition
Type
article
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article

The Role of the Creatine Phosphate System in Energy Storage and Release: From Molecular Mechanisms to Physiological Functions

Wen Huang, Wenying Hong
Journal of Energy Bioscience
Muscle metabolism and nutrition
article

The Role of the Creatine Phosphate System in Energy Storage and Release: From Molecular Mechanisms to Physiological Functions

Wen Huang, Wenying Hong
article en

Abstract

The creatine phosphate system helps process energy in cells, especially in tissues that require a lot of energy and change quickly, such as muscles and brains. This study mainly talks about how the creatine phosphate system works, its basic principles, the pathways involved, and its role in the body. We focused on creatine kinase, which helps cells regenerate ATP, and also plays a role in "storing" energy, and is even responsible for transmitting energy to where it is needed. This process is very critical during muscle contraction and brain function, especially in those organs that use a lot of energy, it can help cells maintain a stable energy state. The article also mentioned that supplementing creatine phosphate may help some diseases, such as muscle diseases and neurodegenerative diseases. Now, because of the increasing advancement of technologies such as molecular imaging and bioinformatics, people have a deeper understanding of how creatine is metabolized and how it cooperates with other cellular processes. In the future, researchers may try to develop some new therapies related to creatine. We will continue to explore how it is regulated at the molecular level and see how it is related to other metabolic pathways. These studies are expected to bring new ideas and treatments for treating some energy-related diseases.

Journal of Energy Bioscience
Hainan Tropical Ocean University (CN)
Affordable and clean energy
Openalex Percentile: Top 80%
Muscle metabolism and nutrition
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The Role of the Creatine Phosphate System in Energy Storage and Release: From Molecular Mechanisms to Physiological Functions — Wen Huang, Wenying Hong · Journal of Energy Bioscience (2025) | TGRS Research Map | TGRS