Cationic and homoleptic copper( <scp>i</scp> )–thiazol-2-ylidenes: highly reactive thiazole N-heterocyclic carbenes as σ-Lewis acid catalysts
Air- and moisture-stable cationic homoleptic Cu(I) thiazol-2-ylidene complexes are developed as highly efficient σ-Lewis acid catalysts, outperforming imidazol-2-ylidenes in the alkynylation of ketones without requiring stoichiometric Cu-acetylides. These complexes exhibit exceptional operational simplicity and robustness, enabling key C-C bond formation. Structural insights and DFT studies highlight their enhanced reactivity and stability. With their superior performance and practicality, thiazol-2-ylidenes represent a promising class of catalysts for sustainable organic synthesis.
Authors
- Yan Guo (ORCID: https://orcid.org/0000-0002-5724-2110)
- Roman Szostak (ORCID: https://orcid.org/0000-0002-5436-7284)
- Jin Zhang (ORCID: https://orcid.org/0000-0002-6616-7087)
- Ruihong Wang (ORCID: https://orcid.org/0000-0001-8370-0106)
- Hangsheng Yang (ORCID: https://orcid.org/0000-0002-5968-9223)
- Michal Szostak (ORCID: https://orcid.org/0000-0002-9650-9690)
- Xiao Han (ORCID: https://orcid.org/0000-0002-0544-4351)
- Yawei Zhu
Institutions
- Rutgers, The State University of New Jersey (US)
- University of Wrocław (PL)
- Shaanxi University of Science and Technology (CN)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5qo00772k
- Citations
- 1
- Primary Topic
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- National Institutes of Health
- Wroclawskie Centrum Sieciowo-Superkomputerowe, Politechnika Wroclawska