Adverse childhood experiences influence markers of neurodegeneration risk in older adults
Adverse childhood experiences (ACEs) may elicit compensatory neural responses in aging. Financial need was associated with lower global cognition (Montreal Cognitive Assessment scores). Some ACEs (e.g., financial need, parental intimidation) linked to lower plasma neurofilament light chain. Parental violence linked to lower glial fibrillary acidic protein and mean diffusivity values, implying intact white mattery integrity.
Authors
- Gabrielle N. Pfund (ORCID: https://orcid.org/0000-0003-2928-752X)
- Deborah Rose
- Negar Fani (ORCID: https://orcid.org/0000-0002-7720-252X)
- James R. Bateman
- Andreana M. Benitez (ORCID: https://orcid.org/0000-0002-8294-7809)
- Keenan A. Walker (ORCID: https://orcid.org/0000-0002-5989-9853)
- Jillian K. Lee (ORCID: https://orcid.org/0000-0002-3793-3950)
- Michelle M. Mielke (ORCID: https://orcid.org/0000-0001-7177-1185)
- Andy Liu (ORCID: https://orcid.org/0000-0003-3096-1788)
Institutions
- Johns Hopkins University (US)
- Emory University (US)
- Medical University of South Carolina (US)
- Duke University (US)
- Johns Hopkins Medicine (US)
- National Institute on Aging (US)
- Wake Forest University (US)
- Auburn University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-07-30
- DOI
- https://doi.org/10.1002/alz.70523
- Citations
- 3
- Primary Topic
- Resilience and Mental Health
- Type
- article
- Field-Weighted Citation Impact
- 6.92
Funders
- Wake Forest University
- National Institutes of Health
- National Institute on Aging