Contemporary Multimodal Approaches in Oral Cancer: An Updated Review

Oral cancer is one of the global health burdens with considerable morbidity and mortality due to its aggressive nature and diagnosing it in later stage. This complex disease with anatomical and functional implications requires a multidisciplinary and multimodal approach for management. In recent years detection and management of oral malignancies gained prominence due to its contemporary multimodal approach. This updated review gives an insight on traditional diagnosis with the advanced techniques like optical imaging, salivary biomarkers and genomic profile. Trending aids like Artificial Intelligence including Machine Learning algorithms may facilitate a more precise diagnosis. The multimodal treatment approach integrates traditional cancer treatment with newer techniques like immunotherapy, gene therapy and precision medicine guided by molecular profiling. This multimodal approach can improve survival rates, reduce recurrence and preserve quality of life with advanced or high-risk oral cancers. This evidence based multimodal approach can achieve better clinical and functional outcomes in oral cancer patients. Keywords: Oral cancer, Multimodal approaches, Artificial Intelligence, Interdisciplinary management