Progression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease
Parkinson's disease (PD) is marked by motor symptoms and often accompanied by mild cognitive impairment (PD-MCI), affecting up to 50% of patients and preceding PD dementia (PDD). Genetic factors may influence this progression, yet the underlying mechanisms remain unclear. This study investigated genetic factors influencing the progression from PD-MCI to PDD using polygenic risk scores (PRS). A genome-wide association study (GWAS) was conducted using data from the LANDSCAPE study. Multivariable Cox regression, Kaplan-Meier survival analysis, and concordance statistics assessed the relationship between PRS and PDD progression. No significant association was found between PD PRS and the risk of developing PDD.
Authors
- Daniela Berg (ORCID: https://orcid.org/0000-0001-5796-5442)
- Rüdiger Hilker-Roggendorf
- J. Alexander Ross (ORCID: https://orcid.org/0000-0001-9286-2748)
- Annika Spottke (ORCID: https://orcid.org/0000-0001-9854-2972)
- Claudia Trenkwalder (ORCID: https://orcid.org/0000-0001-6407-1199)
- Alfredo Ramı́rez (ORCID: https://orcid.org/0000-0003-4991-763X)
- Jörg B. Schulz (ORCID: https://orcid.org/0000-0002-8903-0593)
- Kayenat Parveen
- Richard Dodel (ORCID: https://orcid.org/0000-0003-2044-6299)
- Sandra Roeske (ORCID: https://orcid.org/0000-0002-8262-4356)
- Alexander Storch (ORCID: https://orcid.org/0000-0002-1133-9216)
- Hendrik van der Wurp (ORCID: https://orcid.org/0000-0002-1044-417X)
- Karsten Witt (ORCID: https://orcid.org/0000-0002-9384-3474)
- Elke Kalbe (ORCID: https://orcid.org/0000-0001-8603-2545)
- Thomas Gasser (ORCID: https://orcid.org/0000-0002-1069-1146)
- Günther Deuschl (ORCID: https://orcid.org/0000-0002-4176-9196)
- Inga Liepelt‐Scarfone (ORCID: https://orcid.org/0000-0002-0875-892X)
- Monika Balzer‐Geldsetzer
- Ullrich Wüllner (ORCID: https://orcid.org/0000-0002-3132-0790)
- Carolina Dalmasso (ORCID: https://orcid.org/0000-0002-4901-9955)
- Brit Mollenhauer (ORCID: https://orcid.org/0000-0001-8437-3645)
- Oliver Riedel (ORCID: https://orcid.org/0000-0002-1721-502X)
- Jan Kassubek (ORCID: https://orcid.org/0000-0002-7106-9270)
Institutions
- Goethe University Frankfurt (DE)
- Carl von Ossietzky Universität Oldenburg (DE)
- University of Bonn (DE)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Philipps University of Marburg (DE)
- University of Cologne (DE)
- University Hospital Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- Stuttgart Technical University of Applied Sciences (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- Institute for Neurodegenerative Disorders (US)
- Leibniz Institute for Prevention Research and Epidemiology - BIPS (DE)
- Paracelsus Elena Klinik Kassel (DE)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- Hertie Institute for Clinical Brain Research (DE)
- Evangelisches Krankenhaus Oldenburg (DE)
- University Hospital Cologne (DE)
- University Hospital Ulm (DE)
- University of Rostock (DE)
- University of Duisburg-Essen (DE)
- University of Göttingen (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Journal of Parkinson s Disease
- Published
- 2025-07-30
- DOI
- https://doi.org/10.1177/1877718x251356512
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Innovative Medicines Initiative