Tumor microenvironment responsive TPZ-loaded core-shell polymeric nanoparticles for selective cancer bioreductive therapy
Together, APAP@TPZ as biocompatible, and multi-stage activating platforms afford deepened penetration of HAP to hypoxic tumor core, where PEG detachment and TPZ bioreduction into its active form promote selective and effective eradication of hypoxic breast cancer microtumors.
Authors
- Zohreh Amoozgar (ORCID: https://orcid.org/0000-0001-8285-8024)
- Hamed Hamishehkar (ORCID: https://orcid.org/0000-0001-9905-0662)
- Mohammad Shahpouri
- Mehran Alizadeh Aghdam (ORCID: https://orcid.org/0000-0003-3584-9250)
- Abolfazl Barzegari (ORCID: https://orcid.org/0000-0002-8429-3618)
- Hasan Sh. Majdi (ORCID: https://orcid.org/0000-0001-6752-4835)
- Rana Jahanban‐Esfahlan (ORCID: https://orcid.org/0000-0002-5119-252X)
- Mehdi Jaymand (ORCID: https://orcid.org/0000-0003-1416-4543)
- Sajjad Alimohammadvand (ORCID: https://orcid.org/0009-0007-9568-6322)
- Masoumeh Kaveh Zenjanab
Institutions
- Khazar University (AZ)
- Harvard University (US)
- Tabriz University of Medical Sciences (IR)
- Kermanshah University of Medical Sciences (IR)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Advanced Pharmaceutical Bulletin
- Published
- 2025-06-16
- DOI
- https://doi.org/10.34172/apb.025.43945
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Medical Research Development