Results of treatment of two patients with MALT lymphoma

Introduction. MALT lymphoma is a rare histological type of malignant lung disease that develops from lymphoid tissue. This type of lymphoma belongs to the non-Hodgkin lymphomas. Given the lack of a standardized treatment protocol for patients with pulmonary MALT lymphoma, this study presents a case observation of the treatment of this disease. Each case observation is crucial for establishing a unified treatment strategy. Aim. To demonstrate the effectiveness of comprehensive treatment in two patients with pulmonary MALT lymphoma. Methods . This study presents two clinical cases of successful treatment of patients with MALT lymphoma at the regional clinical oncological dispensary in Ulyanovsk. The authors present their observations and describe the treatment regimens used. One patient underwent a tumor biopsy, which was inconclusive. Given the non-specific clinical presentation and the CT findings of a mass in the right lung with an undetermined histogenesis, as well as mediastinal involvement, surgical intervention was indicated for the morphological diagnosis of the lung mass. In both cases, targeted support with Rituximab was included in the treatment regimen. One case involved five courses of R-B therapy without progression, while in the other case, targeted therapy is planned as the next step after polychemotherapy. Conclusions. MALT lymphoma is a rare nosological form. According to the authors, the most optimal treatment method is a combined approach, which includes surgical treatment, polychemotherapy, and subsequent targeted therapy.