Consequences of Stopping Antiretroviral Treatment in a Persistently Seronegative Individual with HIV-1
This case of HIV-1-seronegative infection due to very early treatment demonstrates that even in the absence of sufficient HIV replication to generate detectable immunity, a competent reservoir can accumulate, allowing replication to resume despite 20 months of effective treatment and the disappearance of molecular evidence of infection.
Authors
- Théophile Cocherie (ORCID: https://orcid.org/0000-0001-5895-6193)
- Amélie Guihot
- Antoine Fayçal
- Vincent Cálvez (ORCID: https://orcid.org/0009-0002-6855-3472)
- Anne‐Geneviève Marcelin (ORCID: https://orcid.org/0000-0003-4808-8999)
- Marc Wirden (ORCID: https://orcid.org/0009-0003-3723-4142)
- A. Gautheret-Dejean (ORCID: https://orcid.org/0000-0003-0048-0318)
- Delphine Sterlin (ORCID: https://orcid.org/0000-0002-5993-687X)
- Roland Tubiana
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Pitié-Salpêtrière Hospital (FR)
- Centre d'Immunologie et des Maladies Infectieuses (FR)
- Institut Pierre Louis d‘Épidémiologie et de Santé Publique (FR)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-07-30
- DOI
- https://doi.org/10.1093/cid/ciaf422
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00