Quercetin ameliorates epithelial-mesenchymal transition and inflammation by targeting FSTL1 and modulating the NF-κB pathway in pulmonary fibrosis
Quercetin exerts its protective effects against pulmonary fibrosis by suppressing FSTL1 expression and modulating the NF-κB signaling pathway, thereby inhibiting both inflammation and EMT process.
Authors
- Jingbin Zhang (ORCID: https://orcid.org/0000-0003-2065-1823)
- Xiaodan Lu (ORCID: https://orcid.org/0000-0001-8554-6325)
- Chuan Dong (ORCID: https://orcid.org/0000-0002-1827-8794)
- Bingxue Qi (ORCID: https://orcid.org/0009-0007-8660-1569)
- Yang Chen (ORCID: https://orcid.org/0000-0002-3132-816X)
- Ren Yuan
- Yuejiao Lan (ORCID: https://orcid.org/0009-0007-2058-7020)
- Zhen Yang (ORCID: https://orcid.org/0000-0002-6032-3018)
- Mingda Wu
- Kunpeng Yang (ORCID: https://orcid.org/0009-0007-2473-6679)
Institutions
- People 's Hospital of Jilin Province (CN)
- Changchun University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-07-30
- DOI
- https://doi.org/10.3389/fphar.2025.1594757
- Citations
- 3
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Natural Science Foundation of Jilin Province
- People's Government of Jilin Province
- Jilin Department of Health