Placental Extract Gel as a Topical Agent for Optimizing Healing of Full-thickness Skin Graft Donor Sites

Full-thickness skin graft (FTSG) donor sites are often closed primarily, particularly when small and located in areas with adequate tissue laxity. Despite primary closure, these sites may still experience delayed healing, discomfort, or hypertrophic scarring. Placental extract gel, derived from human placenta, is rich in growth factors, cytokines, and bioactive peptides known to facilitate wound healing and modulate scar formation through enhanced angiogenesis, anti-inflammatory action, and microbial resistance. Its biocompatibility and regenerative properties make it a promising adjunct in wound care. We report the case of a 12-year-old child with electrical burn raw areas over bilateral feet, for which reconstruction was done using an FTSG harvested from the left groin. The donor site was closed primarily, and placental extract gel was applied topically along the suture line. The wound healed without complications, with suture removal on day 7, and the resultant scar was cosmetically satisfactory. This case highlights the potential role of placental extract gel in enhancing healing and improving early scar quality, even in surgically closed wounds. Further studies may help establish its routine use as a cost-effective and easily applicable adjunct in post-operative wound care.