A Technique for Human Skin Grafting in a Mouse Model

Source: Moss, M. I. et al., Xenograft Skin Model to Manipulate Human Immune Responses In Vivo. J. Vis. Exp. (2022) This video demonstrates a method for grafting human skin onto an immunodeficient mouse with a suppressed neutrophil response. The method involves applying human split-thickness skin to the mouse's graft bed, sealing it, and covering it for recovery. Eventually, the human skin adheres to the mouse's skin, establishing vascularization and circulation, resulting in a successful skin xenograft.