Demyelination and Remyelination of Mouse Spinal Cord Neurons

Source: Keough, M. B., et al. Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin. J. Vis. Exp. (2015) This video demonstrates the method for inducing demyelination in mouse spinal cord neurons using lysolecithin injections, followed by remyelination through the migration and differentiation of oligodendrocyte precursor cells. The process impairs and then gradually restores neuronal signal transmission.

Publication Details

Journal: Journal of Visualized Experiments
Published: 2025-07-24
DOI: https://doi.org/10.3791/31395
Primary Topic: Neurogenesis and neuroplasticity mechanisms
Type: article
Field-Weighted Citation Impact: 0.00

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article

Demyelination and Remyelination of Mouse Spinal Cord Neurons

Jul 24, 2025

Journal of Visualized Experiments

Neurogenesis and neuroplasticity mechanisms

article

Demyelination and Remyelination of Mouse Spinal Cord Neurons

July 24, 2025article en

Abstract

Journal of Visualized Experiments

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Openalex Percentile: Top 78%

Neurogenesis and neuroplasticity mechanisms

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Demyelination and Remyelination of Mouse Spinal Cord Neurons · Journal of Visualized Experiments (2025) | TGRS Research Map | TGRS