Generating A Cortical Stab Injury in a Mouse Model to Induce Reactive Astrogliosis

Source: Allahyari, R. V. et al. Triggering Reactive Gliosis In Vivo by a Forebrain Stab Injury. J. Vis. Exp. (2015) This video demonstrates the cortical stab injury procedure in mice, involving skull exposure and brain lesion creation. It induces reactive astrogliosis, a neuroprotective response of astrocytes, to study CNS trauma, inflammation, and repair mechanisms.