Assessing the Effects of Toxins on Chick Embryo Neural Network Development Using Multielectrode Arrays

Source: Sanchez, K. R., et.al. Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays. J. Vis. Exp. (2018). This video demonstrates the use of multi-electrode arrays (MEA) to study the effects of toxins on early embryonic chick neuronal cultures. By monitoring the synchronous activity of the neurons in the neuronal network, the MEA captures the functional dynamics of the neuronal network in response to toxin exposure. Reduced synchrony and firing rates upon toxin exposure highlight its detrimental impact on neuronal network maturation and function.