Recording Neural Activity in Freely Moving Mice Using Fiber Photometry

Source: Martianova, E., et al. Multi-Fiber Photometry to Record Neural Activity in Freely-Moving Animals. J. Vis. Exp. (2019). This video demonstrates a method for recording neural activity in a freely moving mouse using fiber photometry. In this method, neurons in a specific brain region express a genetically encoded calcium indicator. A stimulus is applied to this brain region, and the stimulus-dependent change in fluorescence is measured to identify neural activity.