Selective Manipulation of Theta Oscillations in a Mouse Model

Source: Bender, F. et al., Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice. J. Vis. Exp (2018) This video demonstrates a protocol to modulate theta oscillations in a genetically engineered mouse model with light-sensitive ion channels in its GABAergic medial septum neurons. By delivering light pulses to the hippocampus, the protocol aims to synchronize neuronal activity and generate theta oscillations, which are recorded as local field potentials.