Generating a Mouse Model of Traumatic Brain Injury Using a Lateral Fluid Percussion Device

Source: Wen, L., et al. Investigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice. J. Vis. Exp. (2019). The video demonstrates a method to generate a mouse model of traumatic brain injury (TBI) using a lateral fluid percussion device (LFPI). Upon anesthetizing the mouse, the brain is exposed by creating a window on the skull. A saline-filled cannula is attached to the window and is then connected to the LFPI. The pendulum of the device is released to create a pressure pulse that inflicts a traumatic brain injury.