Generation of a Murine Model with a Central Nervous System Infection

Source: Shen, T., et al. A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease. J. Vis. Exp. (2019) This video demonstrates the generation of a mouse model with a CNS infection. A suckling pup is injected with the virus both intracranially and intraperitoneally. The virus spreads, infecting the CNS causing neuronal cell death and inflammation. The pup is assessed for symptoms of infection as the disease progresses.

Publication Details

Journal
Journal of Visualized Experiments
Published
2025-07-24
DOI
https://doi.org/10.3791/31357
Primary Topic
Cell Image Analysis Techniques
Type
article
Field-Weighted Citation Impact
0.00
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article

Generation of a Murine Model with a Central Nervous System Infection

Journal of Visualized Experiments
Cell Image Analysis Techniques
article

Generation of a Murine Model with a Central Nervous System Infection

article en

Abstract

Source: Shen, T., et al. A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease. J. Vis. Exp. (2019) This video demonstrates the generation of a mouse model with a CNS infection. A suckling pup is injected with the virus both intracranially and intraperitoneally. The virus spreads, infecting the CNS causing neuronal cell death and inflammation. The pup is assessed for symptoms of infection as the disease progresses.

Journal of Visualized Experiments
Openalex Percentile: Top 87%
Cell Image Analysis Techniques
DOISourceOpenAlex
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Generation of a Murine Model with a Central Nervous System Infection · Journal of Visualized Experiments (2025) | TGRS Research Map | TGRS