Establishing a Whole-Cell Voltage-Clamp Configuration for Electrophysiological Recordings in Brain Slices

Source: Sunstrum, J. K., et al. Evaluation of synaptic multiplicity using whole-cell patch-clamp electrophysiology. J. Vis. Exp. (2019) This video demonstrates positioning a fine-pointed pipette near brain slices, forming a seal with a neuronal cell. Suction breaks the cell membrane, thereby creating a whole-cell patch clamp that enables current measurements for electrophysiology experiments.

Publication Details

Journal: Journal of Visualized Experiments
Published: 2025-07-24
DOI: https://doi.org/10.3791/31192
Primary Topic: Neural dynamics and brain function
Type: article
Field-Weighted Citation Impact: 0.00

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article

Establishing a Whole-Cell Voltage-Clamp Configuration for Electrophysiological Recordings in Brain Slices

Jul 24, 2025

Journal of Visualized Experiments

Neural dynamics and brain function

article

Establishing a Whole-Cell Voltage-Clamp Configuration for Electrophysiological Recordings in Brain Slices

July 24, 2025article en

Abstract

Journal of Visualized Experiments

Openalex Percentile: Top 82%

Neural dynamics and brain function

DOI Source OpenAlex

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Establishing a Whole-Cell Voltage-Clamp Configuration for Electrophysiological Recordings in Brain Slices · Journal of Visualized Experiments (2025) | TGRS Research Map | TGRS