Generating a Middle Cerebral Artery Occlusion in a Rat Pup to Induce Local Brain Ischemia

Source: Larpthaveesarp, A., et. al. Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats. J. Vis. Exp. (2017)This video demonstrates the establishment of the Middle Cerebral Artery Occlusion model in a rat pup. The internal carotid artery (ICA) is exposed, and a ligature is secured to restrict blood flood. An occlude is inserted through the ICA to reach the Middle Cerebral Artery. The pup is then allowed to recover before further analysis.

Publication Details

Journal: Journal of Visualized Experiments
Published: 2025-07-24
DOI: https://doi.org/10.3791/31489
Primary Topic: Neurological Disease Mechanisms and Treatments
Type: article
Field-Weighted Citation Impact: 0.00

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article

Generating a Middle Cerebral Artery Occlusion in a Rat Pup to Induce Local Brain Ischemia

Jul 24, 2025

Journal of Visualized Experiments

Neurological Disease Mechanisms and Treatments

article

Generating a Middle Cerebral Artery Occlusion in a Rat Pup to Induce Local Brain Ischemia

July 24, 2025article en

Abstract

Journal of Visualized Experiments

Openalex Percentile: Top 76%

Neurological Disease Mechanisms and Treatments

DOI Source OpenAlex

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Generating a Middle Cerebral Artery Occlusion in a Rat Pup to Induce Local Brain Ischemia · Journal of Visualized Experiments (2025) | TGRS Research Map | TGRS