Recording Neural Activity of Unfolded Hippocampal Tissue Using Penetrating Microelectrode Array

Source: Zhang, M., et al. Neural Activity Propagation in an Unfolded Hippocampal Preparation with a Penetrating Micro-electrode Array. J. Vis. Exp. (2015). This video demonstrates the procedure to set up a recording chamber with a penetrating microelectrode array (PMEA) to capture neural signals from an unfolded hippocampus. This method allows us to study the speed and direction of propagation of neural activity within the unfolded hippocampus in vitro.