Induction of Cerebral Microhemorrhages in a Rat Model Using Lipopolysaccharide

Source: Li, D., et al. Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats. J. Vis. Exp. (2018). This video demonstrates the process of inducing blood-brain barrier (BBB) disruption and cerebral microhemorrhages in a rat model using lipopolysaccharide (LPS). It highlights the sequence of immune responses that lead to increased BBB permeability and subsequent brain tissue damage.

Publication Details

Journal
Journal of Visualized Experiments
Published
2025-07-24
DOI
https://doi.org/10.3791/31342
Primary Topic
Intracerebral and Subarachnoid Hemorrhage Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Induction of Cerebral Microhemorrhages in a Rat Model Using Lipopolysaccharide

Journal of Visualized Experiments
Intracerebral and Subarachnoid Hemorrhage Research
article

Induction of Cerebral Microhemorrhages in a Rat Model Using Lipopolysaccharide

article en

Abstract

Source: Li, D., et al. Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats. J. Vis. Exp. (2018). This video demonstrates the process of inducing blood-brain barrier (BBB) disruption and cerebral microhemorrhages in a rat model using lipopolysaccharide (LPS). It highlights the sequence of immune responses that lead to increased BBB permeability and subsequent brain tissue damage.

Journal of Visualized Experiments
Openalex Percentile: Top 72%
Intracerebral and Subarachnoid Hemorrhage Research
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Induction of Cerebral Microhemorrhages in a Rat Model Using Lipopolysaccharide · Journal of Visualized Experiments (2025) | TGRS Research Map | TGRS