Assessing Neural Connection Formation in a Co-Culture using Electrophysiological Recordings

Source: Su, C. T. E., et al. An Optogenetic Approach for Assessing Formation of Neuronal Connections in a Co-culture System. J. Vis. Exp. (2015) The video demonstrates electrophysiological recording to assess neural connections between iPSC-derived and rat cortical neurons, confirming synaptic contacts in the co-culture by activating light-sensitive ion channels and detecting postsynaptic currents.