Recording Brain Electrical Activity in Behaving Mice Using Multi-Shank Linear Silicon Probes

Source: Sauer, J., et al. Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice. J. Vis. Exp. (2018). This video outlines a protocol for implanting a multi-shank linear silicon probe into the mouse brain to measure local field potentials. The procedure involves securing the probe to a stereotaxic unit, positioning it accurately over the target brain region, inserting it into the brain, and securing it with dental cement. After implantation, the assembly is protected with a casing. Following recovery, the setup allows for recording local field potentials, providing insights into neuronal activity.