Handling-Induced Seizures in a Mouse Model

Source: Batot, G., et al. A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus. J. Vis. Exp. (2022). This video demonstrates the induction of handling-induced seizures in a mouse infected with Theiler's Murine Encephalomyelitis Virus (TMEV). The infected mouse, which has hyperexcitable neurons, is exposed to external physical stimuli. This exposure causes stress, leading to abnormal electrical activity in the neurons, which results in seizures.