Generating the 6-hydroxydopamine Rat Model of Parkinson's Disease

Source: Guimarães, R. P., et al. The 6-hydroxydopamine Rat Model of Parkinson's Disease. J. Vis. Exp. (2021). This video demonstrates a procedure to create a rat model of Parkinson's disease by injecting the neurotoxin 6-hydroxydopamine (6-OHDA) into the brain. The neurotoxin infusion into the medial forebrain bundle (MFB) specifically targets dopaminergic neurons responsible for motor control, leading to their destruction and replicating Parkinson's disease symptoms.

Publication Details

Journal
Journal of Visualized Experiments
Published
2025-07-24
DOI
https://doi.org/10.3791/31328
Primary Topic
Parkinson's Disease Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Generating the 6-hydroxydopamine Rat Model of Parkinson's Disease

Journal of Visualized Experiments
Parkinson's Disease Mechanisms and Treatments
article

Generating the 6-hydroxydopamine Rat Model of Parkinson's Disease

article en

Abstract

Source: Guimarães, R. P., et al. The 6-hydroxydopamine Rat Model of Parkinson's Disease. J. Vis. Exp. (2021). This video demonstrates a procedure to create a rat model of Parkinson's disease by injecting the neurotoxin 6-hydroxydopamine (6-OHDA) into the brain. The neurotoxin infusion into the medial forebrain bundle (MFB) specifically targets dopaminergic neurons responsible for motor control, leading to their destruction and replicating Parkinson's disease symptoms.

Journal of Visualized Experiments
Good health and well-being
Openalex Percentile: Top 72%
Parkinson's Disease Mechanisms and Treatments
DOISourceOpenAlex
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Generating the 6-hydroxydopamine Rat Model of Parkinson's Disease · Journal of Visualized Experiments (2025) | TGRS Research Map | TGRS