Direct Neuronal Reprogramming of Mouse Astrocytes into Neurons

Source: Hersbach, B. A. et al., Isolation and Direct Neuronal Reprogramming of Mouse Astrocytes. J. Vis. Exp. (2022) This video showcases the direct reprogramming of astrocytes expressing transforming factors into neurons. Transformation factors trigger a cascade of molecular events facilitating astrocyte-to-neuron conversion. The process is further supported by supplying specific agents and supplements through a neuronal differentiation medium.