Differentiation of Spinal Cord Neural Progenitor Cells into Motor Neurons

Source: Taga, A. et al., Establishment of an Electrophysiological Platform for Modeling ALS with Regionally-Specific Human Pluripotent Stem Cell-Derived Astrocytes and Neurons. J. Vis. Exp. (2021). This video showcases a method for differentiating spinal cord neural progenitor cells (NPCs) into motor neurons. It details the culturing process of the NPCs on a coated culture plate using specialized media enriched with specific inhibitors aimed at facilitating NPC differentiation into mature motor neurons.

Publication Details

Journal
Journal of Visualized Experiments
Published
2025-07-24
DOI
https://doi.org/10.3791/31074
Primary Topic
Neurogenesis and neuroplasticity mechanisms
Type
article
Field-Weighted Citation Impact
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article

Differentiation of Spinal Cord Neural Progenitor Cells into Motor Neurons

Journal of Visualized Experiments
Neurogenesis and neuroplasticity mechanisms
article

Differentiation of Spinal Cord Neural Progenitor Cells into Motor Neurons

article en

Abstract

Source: Taga, A. et al., Establishment of an Electrophysiological Platform for Modeling ALS with Regionally-Specific Human Pluripotent Stem Cell-Derived Astrocytes and Neurons. J. Vis. Exp. (2021). This video showcases a method for differentiating spinal cord neural progenitor cells (NPCs) into motor neurons. It details the culturing process of the NPCs on a coated culture plate using specialized media enriched with specific inhibitors aimed at facilitating NPC differentiation into mature motor neurons.

Journal of Visualized Experiments
Zero hunger
Openalex Percentile: Top 79%
Neurogenesis and neuroplasticity mechanisms
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Differentiation of Spinal Cord Neural Progenitor Cells into Motor Neurons · Journal of Visualized Experiments (2025) | TGRS Research Map | TGRS