Sucralose Consumption Ablates Cancer Immunotherapy Response through Microbiome Disruption
This study highlights an unappreciated role of sucralose in reducing immunotherapy efficacy in both mouse models and samples from patients with cancer through shifts in the microbiome and arginine degradation that lead to T-cell exhaustion. T-cell function and immunotherapy responses are restored through amino acid supplementation. See related commentary by Chandra et al., p. 2196.
Authors
- Madison Nguyen (ORCID: https://orcid.org/0009-0008-8341-8694)
- Abigail E. Overacre-Delgoffe (ORCID: https://orcid.org/0000-0003-4027-3487)
- Bingxian Xie (ORCID: https://orcid.org/0000-0001-9816-2670)
- Drew E. Hurd (ORCID: https://orcid.org/0009-0001-3790-0358)
- Diwakar Davar (ORCID: https://orcid.org/0000-0002-7846-8055)
- Ansen B.P. Burr (ORCID: https://orcid.org/0000-0003-2524-897X)
- Zakaria Larbi Dahmani (ORCID: https://orcid.org/0009-0005-8002-3169)
- Larry Kane (ORCID: https://orcid.org/0000-0001-5198-516X)
- Stacy G. Wendell (ORCID: https://orcid.org/0000-0001-9083-6933)
- Kristin M. Morder (ORCID: https://orcid.org/0000-0001-6085-2924)
- Drew N. Wilfahrt (ORCID: https://orcid.org/0000-0001-7364-1931)
- Hector Nieves-Rosado (ORCID: https://orcid.org/0000-0001-8084-0728)
- Dhivyaa Rajasundaram (ORCID: https://orcid.org/0000-0001-7417-8002)
- Michael Morikone (ORCID: https://orcid.org/0009-0004-7413-6020)
- Jishnu Das (ORCID: https://orcid.org/0000-0002-5747-064X)
- Greg M. Delgoffe (ORCID: https://orcid.org/0000-0002-2957-8135)
- Hong Wang (ORCID: https://orcid.org/0000-0003-0477-2908)
- William G. Gunn (ORCID: https://orcid.org/0009-0007-9070-7550)
- Steven J. Mullett (ORCID: https://orcid.org/0009-0005-6971-9288)
- Kaitlin Bossong (ORCID: https://orcid.org/0009-0006-9619-6969)
Institutions
- University of Pittsburgh (US)
- Microelectronica (Romania) (RO)
- University of California San Francisco Medical Center (US)
- UPMC Hillman Cancer Center (US)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-07-30
- DOI
- https://doi.org/10.1158/2159-8290.cd-25-0247
- Citations
- 3
- Primary Topic
- Tea Polyphenols and Effects
- Type
- article
- Field-Weighted Citation Impact
- 4.41