High levels of a comprehensive set of matrix metalloproteinases in endometriotic lesions: validating the key role of cellular senescence in endometriosis pathogenesis
Increased levels of MMP-1, MMP-2, and MMP-3 in endometriotic lesions indicate that endometriosis may have a unique metabolomic signature linked to cell cycle arrest and inflammation. This may contribute to the pathogenesis of endometriosis by facilitating implantation of ectopic endometrium-like tissue in a disturbed immune environment.
Authors
- Laura Palmieri (ORCID: https://orcid.org/0000-0002-2998-8679)
- Eliane Antonioli (ORCID: https://orcid.org/0000-0002-8563-877X)
- Sérgio Podgaec (ORCID: https://orcid.org/0000-0002-9760-6003)
- Helena Malvezzi (ORCID: https://orcid.org/0000-0002-5504-6116)
- Bruna Cestari de Azevedo (ORCID: https://orcid.org/0000-0002-3495-0798)
- Eduardo Varejão Díaz Placencia (ORCID: https://orcid.org/0000-0001-8066-7224)
Institutions
- Hospital Israelita Albert Einstein (BR)
Publication Details
- Journal
- Einstein (São Paulo)
- Published
- 2025-01-01
- DOI
- https://doi.org/10.31744/einstein_journal/2025ao1345
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00