Cu<sub>2</sub>O-mediated regio- and stereoselective one-pot synthesis of (<i>Z</i>)-3-ylidenephthalides from 2-iodobenzoic acids and terminal alkynes
A series of substituted (<i>Z</i>)-3-ylidenephthalides was synthesized from 2-iodobenzoic acids and various terminal alkynes in the presence of Cu<sub>2</sub>O in DMF at 100-130 °C. Our copper(I) oxide-catalyzed reaction requires no additional palladium, ligand, or base, making it an economical and efficient process. This optimized method is applicable to a range of 2-iodobenzoic acids and alkynes with diverse electronic, steric, and stability characteristics.
Authors
- Longqin Hu (ORCID: https://orcid.org/0000-0002-1799-5652)
- Ahmed R. Ali (ORCID: https://orcid.org/0000-0002-1719-6199)
Institutions
- Rutgers, The State University of New Jersey (US)
- Mansoura University (EG)
- Environmental and Occupational Health Sciences Institute (US)
- Rutgers Cancer Institute (US)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob00808e
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00