Vitamin D Co-Supplementation Against Methamphetamine-Induced Nephrotoxicity in Wistar Rats

Methamphetamine (METH) is a white, odorless, bitter-tasting crystalline psycho-stimulant drug related to amphetamine. It is highly addictive and often employed for the potent euphoric effects it produces, similar to cocaine. Vitamin B complex and vitamin D are noted for their potential protective effects against kidney damage. This study is aimed at investigating the effect of co-administration of vitamin B complex and vitamin D on the kidney in methamphetamine-induced nephrotoxicity in adult male Wistar rats. A total of twenty-four (24) adult male Wistar rats weighing 120–140g were grouped into six groups of n=4 each, labeled A to F. Group A served as the control (feed and water only), group B received 10 mg/kg of methamphetamine only, group C received 100 mg/kg of vitamin B complex, group D received 20 mg/kg of vitamin D, group E received 10 mg/kg of methamphetamine and 100 mg/kg of vitamin B complex, while group F received 10 mg/kg of methamphetamine and 20 mg/kg of vitamin D. All substances were administered orally for the duration of twenty-one (21) days. The results showed a statistically significant decrease in total body weight in group B (P<0.05), while groups C, D, E, and F showed significant increases in body weight (P<0.05). The result on organ weight showed a significant increase in group B, but no significant impact in groups C, D, E, and F (P>0.05) when compared to A. The result on urea and creatinine levels are indicated respectively, a 37.99% and 40% significant increase in group B (P<0.05), a slight 3.76% and 10% non-significant decrease in groups C and D (P>0.05), and a slight 5.8% and 7.67% non-significant increase in groups E and F (P>0.05) when compared to A.