Panax notoginseng saponins regulate the polarization of microglia by inhibiting the hematopoietic progenitor kinase 1 signaling pathway
This research confirmed that PNS effectively inhibits M1 microglial polarization while stimulating M2 microglial polarization via HPK1, JNK, and NF-κB signaling pathway suppression.
Authors
- Xin Liu (ORCID: https://orcid.org/0009-0007-9544-7188)
- Dan Li (ORCID: https://orcid.org/0000-0001-6458-6096)
- Jia Liu (ORCID: https://orcid.org/0000-0002-8970-675X)
- Yujie Zhang (ORCID: https://orcid.org/0000-0002-4686-6526)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-6041-4454)
- Jiaqi Yin (ORCID: https://orcid.org/0000-0002-5839-8993)
Institutions
- Xinjiang Medical University (CN)
Publication Details
- Journal
- Neuroreport
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1097/wnr.0000000000002196
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84